منابع مشابه
Assembly, Trafficking and Function of -Secretase
-Secretase catalyzes the final cleavage of the -amyloid precursor protein to generate amyloidpeptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer’s disease. Here, we review the identification of -secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, -secretase was fou...
متن کاملDifferent cofactor activities in γ-secretase assembly
The gamma-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative gamma-secretase components have been identified-presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we use a stepwise coexpression approach to investigate the role of each new component in ga...
متن کاملStructural basis of human γ-secretase assembly.
The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer's disease. Despite recent structural advances, the transmembrane segments (TMs) of γ-secretase remain to be specifically assigned. Here we report a 3D structure of human γ-secretase at 4.32-Å resolution, determined by single-particle, electron cryomicroscopy in the presence of digitonin a...
متن کاملNELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.
The Negative Elongation Factor (NELF) is a transcription regulatory complex that induces stalling of RNA polymerase II (Pol II) during early transcription elongation and represses expression of several genes studied to date, including Drosophila Hsp70, mammalian proto-oncogene junB, and HIV RNA. To determine the full spectrum of NELF target genes in Drosophila, we performed a microarray analysi...
متن کاملOn Stalling in LogP
We investigate the issue of stalling in the LogP model. In particular, we introduce a novel quantitative characterization of stalling, referred to as δ-stalling, which intuitively captures the realistic assumption that once the network’s capacity constraint is violated, it takes some time (at most δ) for this information to propagate to the processors involved. We prove a lower bound that shows...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1765iti1